| ncRNA name | hsa-miR-145 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB cell line Y79; human embryonic kidney cell line HEK293T |
| Methods | microarray, luciferase reporter assay, qRT-PCR, immunoblot, animal xenograft |
| Expression pattern | associated |
| Functional description | Through post-transcriptional regulation of ABCE1, miR-145 functioned as a key downstream effector in genistein-mediated tumor suppression in retinoblastoma. Moreover, the in vivo data consolidated the inhibitory effect of genistein against retinoblastoma xenograft via upregulation of miR-145. |
| PubMed ID | 28706438 |
| Year | 2017 |
| Title | Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1. |
| Drug-related ncRNA | NO |
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